'Significant concern' for the English camp as Atkinson is forced off due to a hamstring issue.
The pace bowler further complicated the fitness woes of the England squad upon exiting the ground on the second morning of the Boxing Day Test against Australia.
The pace bowler experienced discomfort in his left hamstring after the final ball that he bowled during the morning session.
The England team indicated Atkinson had experienced "tightness" and was to take time off the field in order to be assessed "in the coming hours".
The concluding match in this Ashes battle in Sydney gets underway on Sunday, 4 January.
The English side has been without strike bowlers Mark Wood due to knee trouble and Jofra Archer because of a side injury during this series.
Matthew Fisher was brought into the squad as injury reinforcement.
Atkinson struggled early in the series, managing only three wickets.
He was dropped for the Adelaide match, before being recalled for the Boxing Day match as Archer's replacement.
Atkinson performed better in the fourth Test, claiming a couple of wickets in Australia's first innings, then making 28 with the bat among just a trio of English batsmen to get into double digits.
Following a brief spell at the end of day one, he returned on Saturday morning and removed Scott Boland edging to the keeper.
Yet, at the end of his spell, he delivered a change of pace to the batsman and suddenly grabbed his left hamstring.
The English bowler was recalled for the fourth Ashes Test following his omission the previous Test.